Friday, October 10, 2014


Ah yes!!! Lab-created penises and vaginas! Truly brilliant luciferian creations! Just think of the possibilities when sex and reproduction can happen without the need to include any of those bothersome humans! And imagine how empowering it will feel to destroy the Creator's pristine works by mutilating and transforming men and women into chimeras by giving them the genitals of the opposite sex! How very exciting!!! And let's not forget the multitude of opportunities that will be forthcoming to torture hundreds, perhaps thousands, of animals in order to make these scientific/satanic "advances" possible!!!

Hot damn fellas!!! It's party time!! Who could ask for anything more?

Source Article:
Laboratory Grown Vaginas Successfully Transplanted Into Patients

Tissue engineered hearts and lungs may be still at the laboratory stage, but replacement vaginas made from the patient's own cells have been around for a while. A paper in the Lancet confirms they continue to work years after surgery.

The four patients in the study had Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, which affects women who are genetically and hormonally normal but have an absent or greatly shortened vagina. MRKH may also produce a missing or defective cervix and uterus. Sex is usually painful for women with the condition and more than half a million are affected worldwide.

While we are some way from being able to enable most women with MRKH to conceive, the Wake Forest School of Medicine created sheets from biodegradable scaffolds and epithelial and muscle cells of four girls aged 13-18 with MRKH. These were then “hand-sewn into a vagina-like shape” in the authors' words and implanted. Each vagina was shaped by the Federico Gomez Children's Hospital, Mexico, to best match the body of the woman it was for.

Follow-ups over the next 6-8 years using physical examination, tissue biopsies and MRIs indicated that blood vessels had connected to the implant and within months new cells formed spontaneously while the scaffold was slowly absorbed. A tri-layered structure remained in place after the scaffolding was gone and no abnormalities were observed. The women responded to a questionnaire with responses in the normal range in regard to arousal, lubrication, orgasm and painless intercourse. Most significantly, the patients reported high satisfaction with the replacement vaginas.

Other existing treatments for MRKH are much more traumatic and have a high rate of failure and complication. Team leader Anthony Atala has used a similar technique to build replacement bladders for nine children in need, and has implanted urethras in boys, although there is yet to be the long-term confirmation of success in that case.

Vagina built in the lab from patient's cells

"This pilot study is the first to demonstrate that vaginal organs can be constructed in the lab and used successfully in humans," Atala said. "This may represent a new option for patients who require vaginal reconstructive surgeries. In addition, this study is one more example of how regenerative medicine strategies can be applied to a variety of tissues and organs."

“I truly feel fortunate, because I’ll have a normal life,” a patient who wished to remain anonymous said in a video provided by the Federico Gomez Hospital . “It’s important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment.” Besides MRKH the process could be suitable for women whose vaginas have been damaged in trauma or by cancer. The announcement has generated excitement in the trans community.

Source Article:
Lab-Grown Penis In Final Steps Of Testing: Why A Sense Of Normalcy Is More Than Just An Erection

Becoming a victim of dismemberment due to a car accident, time spent on the battlefield, or being born with a genital abnormality, can lead to grievous psychological complications throughout a man’s life. Researchers at the Wake Forest Institute for Regenerative Medicine in North Carolina recognized the mental and emotional hurdles a man without a penis would lead with the possibility of gender identity loss and a self-conscious romantic life. After nearly 25 years of laboratory grown penis experiments, researchers have reached the safety stage and will soon be testing on human men.

"The rabbit studies were very encouraging," Dr. Anthony Atala, a pediatric urological surgeon and the director of the Institute, who oversaw the team's successful engineering of penises for rabbits in 2002 and 2008, told The Guardian. "But to get approval for humans we need all the safety and quality assurance data, we need to show that the materials aren't toxic, and we have to spell out the manufacturing process, step by step."

Atala began his work in 1992, specializing in treating children born with genital abnormalities. After finding success in the earlier stages of Atala’s penis project in 2002, he said it was not only impressive that they were able to reconstruct a penis, but a real medical milestone in tissue and organ engineering because the penis is one of the most complex organs they’ve attempted to engineer. His team already successfully created fully functional bladders in 1999, but the penis has several functions to complicate the process, unlike the bladder.

The penis is still unable to achieve an erection, which limits them from penetration and ultimately our most fundamental instinct: reproduction. But the function of a penis goes beyond the physical aspect and enters an important realm in a male’s mental perspective. Without a penis, a man can experience castration anxiety, which Sigmund Freud discussed in one of his earliest psychoanalytic theories based on the overwhelming fear of damage or loss of one’s penis. It’s typically caused by already existing penile damage that haunts a man throughout his life, even if it hasn’t limited his sexual reproduction.

With the alarming rate of mutilation to the U.S. troops in Afghanistan, it is of utmost importance a man reinstates his identity by having a penis despite its inability to achieve an erection. The number of U.S. soldiers who experienced severe genital wounds tripled in 2011, and the loss of one limb doubled from 2008 to 2010 because of an increase in improvised explosive devices (IED) used on the battlefield, according to the Army Times. One Marine, and undoubtedly many more, reported if he lost his manhood he wouldn’t want to live through it. This isn’t about just being able to have sex; this is ensuring men have the ability to identify their gender and to reinstate strength and masculinity after such a devastating loss.

"Our target is to get the organs into patients with injuries or congenital abnormalities," said Atala, whose research is currently funded by the U.S. Armed Forces Institute of Regenerative Medicine with a long-term goal of providing penis regrowth procedures for soldiers sustaining battlefield injuries. However, his original passion stemmed from preventing newborn baby boys from being given a sex-change at birth due to being born with ambiguous genitalia. "Imagine being genetically male but living as a woman. It's a firmly devastating problem that we hope to help with."

Limitations Of Laboratory Penises

Currently, the method limits Atala’s team from providing female-to-male sex reassignment surgery because it requires a patient’s own penis-specific cells. These newly grown penises have only gone through testing with rabbits and are currently undergoing the safety, function, and durability testing to prepare them for human testing in the next five years. The penises are used with a donor penis and sanitized to expunge any donor cells and then the male patient’s own cells are grown in culture for four to six weeks and injected into the shaft — muscle and blood vessel cells and all. The trick is using a male’s own cells to dramatically decrease the risk of immunological rejection, which occurs when the body recognizes it as a foreign and dangerous invader.

"My concern is that they might struggle to recreate a natural erection," Atala said. "Erectile function is a coordinated neurophysiological process starting in the brain, so I wonder if they can reproduce that function or whether this is just an aesthetic improvement. That will be their challenge."

When first tested with genetically engineered penises in 2002, once the 18 rabbits recovered from their surgery, they attempted to have sex within 30 seconds of being placed in a cage with a female. Atala reported they were able to penetrate and produce sperm with their new generated penises, but at about the stamina and efficacy of a 60-year-old penis, versus their goal of a 30-year-old. Now with the advent of a nearly complete lab-generated penis, Atala and his team hope to achieve erections for sexual intercourse. What is the point of having a penis if you can’t fulfill the most fundamental and innate function of reproduction — arguably the reason for our existence?

"If we can engineer and replace this tissue, these men can have erections again," said Dr. James Yoo, a collaborator of Atala's at Wake Forest Institute, who is working on bioengineering and replacing parts of the penis to help treat erectile dysfunction. "As a scientist and clinician, it's this possibility of pushing forward current treatment practice that really keeps you awake at night."

Source Article:
Engineered vaginas grown in women for the first time

Vaginas grown in a lab from the recipients' own cells have been successfully transferred to the body for the first time.

The surgery was carried out on four women who were born without vaginal canals because of a rare condition. The women, who were teenagers at the time of the operation, now have fully functioning sexual organs.

"After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," says Anthony Atala at Wake Forest School of Medicine in North Carolina, who led the research. He published the results only after four to eight years had elapsed following surgery, enough time for him to be sure there were no long-term complications.

The four women had undeveloped vaginas because they all have a severe form of a condition called Mayer-Rokitansky-K├╝ster-Hauser Syndrome (MRKH), which affects about 1 in 5000 women. They also had some abnormal development of the uterus, although they did have a vulva – the external part of the sex organ which includes the labia and the clitoris. They were not able to have penetrative sex or menstruate. One of the women was diagnosed after her menstrual blood had collected in her abdomen.

As well as having physical implications, a diagnosis of MRKH is also a huge psychological burden for women.

Maturity challenge

Building on techniques the group developed in the 1990s and perfected on rabbits, Atala and his colleagues removed a small part of the vulva from each woman and grew the cells in the lab. After about four weeks they had enough cells to begin to lay them on to a degradable scaffold one layer at a time "like the layers of a cake", he says.

The challenge was how to get the cells to grow to the right level of maturity in the lab, says Atala. You need to make sure that the cells are mature enough so that when you implant them into the body, they can recruit other cells in the body to form tissue that includes nerves and blood vessels.

Working with surgeons at the Federico Gomez Children's Hospital of Mexico in Mexico City, Atala's team used MRI scans to calculate the appropriate shape and size of the scaffolds for each patient. After cells had established themselves on these scaffolds, surgeons created a cavity in the abdomen and inserted the engineered vagina. It was then stitched in place, connected at the top to the uterus.

The women used a stent for six weeks to make sure the structure maintained the right shape.

The scaffold was made of a collagen matrix and degraded spontaneously over the months following surgery. In that time, the implanted cells matured into the normal tissue of the vaginal wall, including the right layers of muscle and epithelial cells (see video). The vagina was fully developed after six months, and the women were able to menstruate and have sex.

Better than a skin graft

Atala hopes that in the future, the technique could be used to treat not only women who have congenital vaginal defects but also those who have suffered damage through trauma – for instance, because of a car accident or cancer.

Currently it is possible to surgically create vaginas using grafts from either intestinal or skin tissue, but these can lead to severe complications. Skin cell grafts do not provide lubrication which causes pain during sex, and can thicken to the point where the vagina closes. Intestinal cells secrete mucus constantly, which is unhygienic and causes an unpleasant odour. Using the women's own cells from the vulva gets around these issues.

Knowing that the engineered tissue originates from the recipient's own body can be reassuring for them, says Sylvie Miot at the University of Basel, Switzerland, whose team has also successfully engineered new nostrils for patients who had to have skin cancers removed from their nose. Their findings are being published in the same issue of the Lancet.

Both studies involved small numbers of patients, but they provide the first strong evidence that nerve and blood vessels can reconnect to large patches of bioengineered tissues directly inside the body.

Normal life

The findings also show that lab-engineered organs can grow to maturity healthily inside the body, says Martin Birchall at University College London. The women were aged between 13 and 18 years old when the surgery took place so their bodies were still developing. Birchall, who pioneered the first transplant of a human windpipe using the recipient's stem cells, calls the results "very meaningful".

One of the recipients, who wished to remain anonymous, said the treatment opened up new possibilities. "I truly feel fortunate, because I'll have a normal life – completely normal," she says. "It's important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment."

Two of the four women have a functional uterus, so the big question is whether they will be able to have children. "They haven't tried," says Atala, "but they can ovulate, so there is no reason to suspect that they cannot."

Journal references: The Lancet, DOI: 10.1016/S0140-6736(14)60542-0 and 10.1016/S01460544-4